Bio.MeTM Femme V is a multi-strain probiotic formula, containing specific strains that have been clinically researched for their ability to colonise the vaginal microbiome and reduce bacterial vaginosis and its re-occurrence(1). All strains have gone through in-vitro, ex-vivo and in-vivo testing for efficacy, mode of action and safety parameters. Bio.MeTM Femme V Mechanisms of Action
1. Proven colonisation from oral ingestion to vaginal microbiome with strains that have been shown to reduce bacterial vaginosis(1).
2. Strains with anti-microbial activity in the vagina by outcompeting pathogens and reducing vaginal pH, which creates an unfavourable environment for pathogens and opportunistic pathogens, or pathobionts(2).
3. Improving immunity via induction of anti-inflammatory interleukins(1,3). Vaginal Microbiome Health A vaginal microbiota that is dominant in Lactobacillus species has been positively correlated with vaginal and reproductive health, and a decreased tendency to bacterial, fungal and viral vaginal infections(4).
A healthy vaginal microbiome is also correlated with a lower tendency of urinary tract infections (UTI), bacterial vaginosis (BV) and pelvic inflammatory disorder (PID)(5). Of all the Lactobacillus species in the vagina, Lactobacillus crispatus is the biggest lactic acid producer. Lactic acid is crucial in maintaining homeostasis within the vaginal ecosystem, largely by maintaining an acidic vaginal pH below 4.5.
This has been shown to reduce the susceptibility to overgrowth of diverse species, which are implicated in a range of vaginal infections. These include BV, UTIs, and thrush, such as Gardnerella vaginalis, Atopobium vaginae, Candida albicans, Escherichia coli, amongst others(2,6). Lactobacillus crispatus is theorised to bring stability to the normal microflora of the vagina, and is highly dominant in pregnancy, in which it is thought to reduce infections that can cause pre-term births(7). Even though Bifidobacterium is not found in high amounts in the vagina, it has been selected to be used in this formulation for its ability to produce B vitamins, which are a mandatory substrate for the growth of beneficial bacteria. Its activity may have a synergistic effect on the colonisation and proliferation of other beneficial species in the gut first, and then in the vaginal tract.a.