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S-Adenosylmethionine (SAM-e or SAMe; pronounced "sammy") is an amino acid. SAM-e was discovered in 1952 in Italy, where it is manufactured. Until recently, it was exceedingly expensive to produce, and therefore unavailable to the public, although it is well studied. It is manufactured in the brain from another amino acid, methionine. SAM-e is the most active methyl-donor in the body, meaning it donates methyl groups to other chemical compounds in the body including neurotransmitters, changing them into other compounds. SAM-e is then "recycled" through an ongoing re-methylation process.

This is the original SAM-e, S-Adenosylmethionine tosylate disulfate, as developed in Italy and patented in the US. The manufacturing of this product is extremely difficult; it must be produced in a dry environment and transported packed in dry ice. It is then stabilized and double-enteric coated. This coating ensures that it is absorbed through the small intestine, since SAM-e is destroyed in the stomach. Our SAM-e is guaranteed 96.3% pure S-Adenosylmethionine tosylate disulfate (some flow agents must be added in the manufacturing process), produced under dry conditions and properly transported as described above. Made and packaged in the United States using ingredients made in Italy. Cold-glue blister-packed to ensure maximum freshness.